Advancing research for CANVAS

What is RFC1 disease?

RFC1 disease, most commonly known as CANVAS (Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome), is a rare genetic neurological condition that affects balance, coordination, and sensory nerve function. It is caused by an expanded repeat in the RFC1 gene, which disrupts communication between the brain, inner ear, and peripheral nerves.

Symptoms often develop gradually in adulthood and may include imbalance, sensory loss, and sometimes a chronic cough years before neurologic changes appear.

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Our Mission

The RFC1 Foundation is dedicated to:

  • improving awareness

  • accelerating research

  • supporting individuals and families affected by this under-recognized condition.

  • promoting earlier recognition and diagnosis through clear, accessible information.

Dr. Allan Tissenbaum’s story

For years, I diagnosed patients. I did not expect to become one of medicine’s missed diagnoses.

For more than two decades, I lived with a chronic cough….Read more